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A new way of monitoring 
patient-specific COVID-19 immunity

Antibody levels wane over time and vary considerably from individual to individual. Monitoring the immune response is particularly crucial for at-risk individuals subject to COVID-19 exposure. Additionally, everyone can benefit from our novel test's capabilities.

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The KSL COVID-19 Immune Index™ immunoassay detects an individual's IgG, IgM, and IgA antibodies to help you understand your immunity.

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A quick-and-easy finger-prick blood test or blood draw provides accurate, quantitative results to inform decisions regarding vaccination and risk of infection. Contact KSL Diagnostics for testing supplies. Laboratory results can be provided in just days.

Overview

KSL COVID-19 Immune Index™ — Correlation of antibody titers with virus neutralization

Graphical Results

HIGH RISK

IgG results < 10
show low virus neutralization

Correlated antibody levels detected against COVID-19 are considerably low.

If unvaccinated, consider vaccination.

If vaccinated, it may be time for a booster — ask your doctor or visit cdc.gov for recommendations

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MODERATE RISK

IgG titers of 10-20 reduces effective virus neutralization by 25%

Correlated antibody levels detected are moderate. If unvaccinated, consider vaccination. If vaccinated, it may be time for a booster — ask your doctor or visit cdc.gov for recommendations

mod-risk.png

LOW RISK

IgG titers > 20
show 100% neutralization
of virus

COVID-19 antibody levels detected are abundant.. You should still take appropriate precautions and follow public health regulations, your COVID-19 antibodies from prior infection or vaccination are working to protect you.

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References

  • Lau EHY, Tsang OTY, Hui DSC, Kwan MYW, Chan W-H, Chiu SS, et al., 2021. Neutralizing antibody titres in SARS-CoV-2 infections. Nat Commun 12:63. https://doi.org/10.1038/s41467-020-20247-4

  • Suresh L. Six-month longitudinal antibody kinetics of mRNA COVID-19 vaccines. Rheumatology & Autoimmunity 15 September 2021 https://doi.org/10.1002/rai2.12005

  • Valcourt EJ, Manguiat K, Robinson A, Lin Y-C, Abe KT, Mubareka S, et al., 2021. Evaluating humoral immunity against SARS-CoV-2: validation of a plaque-reduction neutralization test and a multi laboratory comparison of conventional and surrogate neutralization assays. Microbiol Spectr 9: e00886-21. https://doi.org/10.1128/Spectrum.00886-21.

  • Jacobs A, Riley S, Smith L, Rushton J, Shen L, Suresh L. Correlation of Antibody Levels with SARS-CoV-2 Virus Neutralization. Congress of Clinical Rheumatology 2022- East, Destin, Florida.

  • Suresh L, Shen L, Rushton J, Riley S, Smith L, Jacobs A. IMMUNE INDEXTM: A Test that correlates antibody levels with SARS-COV-2 Virus neutralization. 13th International Autoimmunity Congress 2022, Athens, Greece

  • Shukla A, Schultz S, Rushton J, Shen L, Suresh L. Dry Blood Spot: An Alternate Sample Type for Measurement of SARS-CoV-2–specific antibodies. 13th International Autoimmunity Congress 2022, Athens, Greece

  • Ghione, P., Gu, J. J., Attwood, K., Torka, P., Goel, S., Sundaram, S., Hernandez-Ilizaliturri, F. J., et al. (2021). Impaired humoral responses to COVID-19 vaccination in patients with lymphoma receiving B-cell–directed therapies. Blood, The Journal of the American Society of Hematology, 138(9), 811-814. https://ashpublications.org/blood/article/138/9/811/476275/Impaired-humoral-responses-to-COVID-19-vaccination

  • Goel, S., Gu, J. J., Torka, P., Mavis, C., Sundaram, S., Neiders, M., Ghione, P., et al. (2021). Determinants of COVID-19 Vaccine Response in Patients with Lymphoma on B Cell Directed Therapy. Blood, 138, 1340. https://www.sciencedirect.com/science/article/pii/S0006497121033140

  • Suresh, L. (2021). Update on COVID-19 vaccines and autoimmune-mediated rheumatic diseases. Reumatologia, 59(4), 203.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436795/

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